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Ronald Ross Watson – DHEA in Human Health and Aging
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Ronald Ross Watson – DHEA in Human Health and Aging
Reduced production of DHEA associated with the diseases that accompany aging has led to its use as a nutritional supplement for antiaging, metabolic support, and other purposes. While animal studies have clearly shown substantial benefits of DHEA in combating various disease states, the effect of low levels of DHEA in humans is less established, and the mechanisms of action and potential involvement in illnesses remain unclear. DHEA in Human Health and Aging reviews the past ten years of research into this hormone and explores its potential for future study.
With contributions from a cadre of international experts, this volume examines:
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- The biology of DHEA relevant to health in humans
- Areas of potential clinical importance concerning low levels of DHEA related to age or physiological change
- Prevention as well as treatment of various human disease states by changing DHEA levels
- The use of DHEA levels in predicting the risk of disease
- The role of DHEA in diabetes, fitness, infectious disease, cancer, AIDS, bone health, cardiovascular diseases, autism, and mental health
- Animal models and their relation to studies done on humans
- The effects of loss of adrenal gland function, the subsequent reduction in DHEA production, and its replacement as therapy
- Adverse effects in DHEA-supplemented women
- Mechanisms of action of DHEA in prostate and ovarian health, vascular modification, stress, memory, aggression, and Alzheimer’s disease
Covering a wide range of topics, the book is compiled from contributions of experts who have each studied some aspect of DHEA and human or animal health or disease. Every chapter is self-contained, allowing for focused study on individual topics. Edited by one of the leading experts in the field of nutrition, the book presents a compelling view of the state of the science in DHEA.
Table of ContentsOverviews of Key DHEA Modified Conditions
DHEA versus Androstenediol in Middle-Aged Women; B. L. Lasley
DHEA as a Putative Replacement Therapy in the Elderly; A. D. Genazzani and C. Lanzoni
Prevention of Disease by DHEA
Dehydroepiandrosterone: Its Metabolites and Resistance to Infections; R. M. Loria and D. Ben-Nathan
DHEA and Glucose Metabolism in Skeletal Muscle; K. Sato and R. Ajisaka
DHEA and Dyskinesias; M. Hamann and A. Richter
Dehydroepiandrosterone: Its Effects on Cell Proliferation and Cancer; R. López-Marure
Dehydroepiandrosterone and Energy Metabolism; S. S. Katyare and H. R. Modi
Dehydroepiandrosterone in Human Immunodeficiency Virus Infection Monitoring and Therapy; R. Kannangai and G. Sridharan
Dehydroepiandrosterone Replacement and Bone Mineral Density; DHEA and Vascular Health and Functions; R. Paulin, E. Dumas De La Roque, and S. Bonnet
DHEA and Ischemia/Reperfusion Injury Prevention; H. Aksoy
DHEA and Cancer Risk or Prevention? F. Labrie
Dehydroepiandrosterone in Intracellular Infectious Diseases and Related Pathogens; N. Galindo-Sevilla and J. Mancilla-Ramírez
Treatment of Diseases and Physiological Disorders by Dehydroepiandrosterone
Dehydroepiandrosterone Sulfate and Vascular Remodeling; M. Ii
DHEA in Human Immunodeficiency Virus Infection: Prognostic and Therapeutic Aspects; C. M. Romero, E. P. Liao, B. Zumoff, and L. Poretsky
DHEA and Its Metabolites and Analogs: A Role in Immune Modulation and Arthritis Treatment? D. L. Auci, C. N. Ahlem, C. L. Reading, and J. M. Frincke
Asthma and DHEA; I. S. Choi
DHEA in Allergy, Asthma, and Urticaria/Angioedema; A. Kasperska-Zajac
The Role of DHEA in Mental Disorders; I. Pérez-Neri and C. Ríos
DHEA, Androgen Receptors, and Their Potential Role in Breast Cancer; Z. Nahleh and N.Tageja
DHEAS and Periodontal Status in Older Japanese; A. Yoshida and T. Ansai
DHEA Levels and Increased Risk of Atherosclerosis and Cardiovascular Disease; I. Kanazawa and T. Yamaguchi
DHEAS and Related Factors in Autism; J. Croonenberghs, K. Van Praet, D. Deboutte, and M. Maes
Animal and In Vitro Model Studies: Future Uses of DHEA
DHEA Antiviral Properties in Cell Cultures and Animal Models; V. Castilla and M. B. Wachsman
Adipose Tissue as a Target for Dehydroepiandrosterone and its Sulphate; F. Pérez-de Heredia, J. J. Hernández-Morante, and M. Garaulet
Dehydroepiandrosterone and Cell Differentiation; A. W. Krug
DHEA, Oxidative Stress, and Akt; M. H. V. M. Jacob, A. S. R. Araújo, M. F. M. Ribeiro, and A. Belló-Klein
Evidence for a Cellular DHEA Receptor; B. O’Leary and J. S. Dillon
DHEA and Mechanisms of Action in Humans
Dehydroepiandrosterone and Testosterone: Effects on Erectile Function; A. I. El-Sakka
DHEA Metabolism, Supplementation, and Decline with Age: Role on Prostate Health; J. T. Arnold
DHEA and Vascular Function; S. Rice and A. Rees
DHEAS and Coping Capability; C.-H. Kuo
DHEA and Memory; E. Sujkovic, R. Mileusnic, and J. Fry
DHEA and Aggression; G. E. Demas, K. K. Soma, and H. E. Albers
DHEA and Alzheimer’s Disease; L. El Kihel
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